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1.
J Pharm Bioallied Sci ; 14(Suppl 1): S298-S300, 2022 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-36110585

RESUMEN

Introduction: The general health of the individual can be calculated using the body mass index (BMI). In our study, we aim to evaluate the association of the BMI to the oral hygiene (OH) and dental caries (DC), in the school pupils. Materials and Methods: We piloted a cross-sectional study with 1000 participants of the ages 5-15 years with mixed dentition. We evaluated the BMI and the Oral Hygeine Index (OHI), DC. We compared the two oral parameters among pupils to the BMI using "ANOVA and Logistic regression analysis" for the identification of the significance and correlation. Results: We observed a significant variation for the different categories of the BMI and the OH, DC. BMI and the OHI, DC both depicted a strong and positive correlation. Conclusions: The nutritional status and the oral health are interrelated. Good oral health has to be promoted for the better general health.

2.
J Pharm Bioallied Sci ; 14(Suppl 1): S292-S294, 2022 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-36110605

RESUMEN

Introduction: Dental caries is a common oral disease that still needs to be thoroughly evaluated for understanding the pathophysiology. Hence, in our study, we evaluate the physicochemical and the peptide properties of the saliva and their role in dental caries among children. Materials and Methods: We conducted an observational in vitro study among 100 subjects of age 5-15 years. Decayed, missing, and filled surface (DMFT)/dmft was used to calculate the caries activity. The unstimulated saliva was evaluated for the peptides "LL-37, human neutrophil peptide (HNP) 1-3, and human beta-defensin-3" by ELIZA and for the "pH, buffer, and flow rate" of the saliva. The data thus obtained were analyzed to correlate caries and the salivary physiochemical and peptides using the "linear regression analysis." P < 0.05 was deliberated as significant. Results: Although no statistically significant variation was seen between low and high caries risk groups and the salivary parameters in our study, we observed a negative correlation of the salivary peptides and caries. For the salivary peptide "HNP1-3," there was a statistically significant variation. Conclusion: The salivary peptides may be carioprotective. However, further research has to be done to establish the mechanism of the action of these substances against caries.

3.
J Pharm Bioallied Sci ; 13(Suppl 2): S1280-S1285, 2021 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-35017971

RESUMEN

INTRODUCTION: A good endodontic sealer aids in a successful root canal treatment. Sealer in turn depends on the thorough irrigation technique and debris removal. Hence, in the present study, we intend to compare the sealer's dispersion into dentinal tubules of the different irrigation systems by confocal laser scanning microscopy (CLSM). METHODOLOGY: Seventy-six single-rooted, freshly removed human mandibular premolars were taken. They were separated into equal groups as conventional endodontic needle irrigation system, Endovacirrigation, Endoactivator irrigation, and manual dynamic agitation groups. Protaper rotary system was used and obturation was done with gutta-percha. The sealer used was AH Plus labeled with fluorescent dye (0.1% Rhodamine B isothcyanate). Transverse sections from the root apex at the levels of 1 mm, 3 mm, and 5 mm were scanned using CLSM. The sealer's penetration for the depth and the percentage were measured. RESULTS: We observed that endovac irrigation system showed maximum percentage and depth of sealer's penetration compared to endoactivator, manual dynamic agitation, and conventional methods at 1, 3, and 5 mm levels from the apex. CONCLUSION: The irrigation systems significantly influence the penetration of the Sealer into root dentinal tubules. When penetration of sealer at different levels, compared to endoactivator, manual dynamic agitation, and conventional method, significant greater levels were attained with the EndoVac system.

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